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HelpTest Code SPASU Arsenic Speciation, 24 Hour, Urine
Specimen Required
Patient Preparation:
1. For the 48-hour period prior to start of collection, as well as during the collection, patient should not eat seafood.
2. High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine collection container
Submission Container/Tube: Plastic, 10-mL tube or a clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 10 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. Refrigerate urine specimen within 4 hours of completion of 24-hour collection
3. See Metals Analysis Specimen Collection and Transport for complete instructions.
Additional Information: For multiple collections see Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens
Useful For
Diagnosing arsenic intoxication using 24-hour urine specimens
Testing Algorithm
Total arsenic will be performed first. If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed and reported. If total arsenic is below 10 mcg/L, total arsenic will be reported as less than 10 mcg/L and speciation will not be performed.
Special Instructions
Reporting Name
Arsenic Speciation, 24 Hr, USpecimen Type
UrineSpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reference Values
TOXIC ARSENIC
<35 mcg/L
Reference values apply to all ages.
Arsenic Speciation Interpretive Information:
The toxic arsenic concentration represents the sum of the inorganic and methylated arsenic species. The reference value for toxic arsenic is <35 mcg/L. This value is based on the American Conference of Governmental Industrial Hygienists (ACGIH) Biological Exposure Index (BEI), which does not include the non-toxic organic arsenic.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82175
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SPASU | Arsenic Speciation, 24 Hr, U | 96253-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 609384 | Inorganic Arsenic (Toxic) | 41992-9 |
| 609385 | Methylated Arsenic (Toxic) | 96252-2 |
| 609386 | Organic Arsenic (Non-Toxic) | 43181-7 |
| 609406 | Toxic Arsenic Concentration | 96251-4 |
| 609387 | Total Arsenic Concentration | 21074-0 |
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysMethod Name
Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)/Ion Chromatography Inductively Coupled Plasma Mass Spectrometry (ICP-MS)