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Test Code RMPU Monoclonal Protein Studies, Random, Urine


Ordering Guidance


The use of a random urine specimen is sufficient for identifying the presence or absence of monoclonal proteins, but a 24-hour specimen is preferred for quantitating and monitoring the abnormality. See SMPU / Monoclonal Protein Studies, 24 Hour, Urine.



Shipping Instructions


Refrigerate specimen during collection and send refrigerated.



Specimen Required


Supplies: Urine Container, 60 mL (T313)

Submission Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 50 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Aliquot between 30 mL and 50 mL of urine into a plastic, 60-mL urine bottle.


Useful For

Identifying monoclonal gammopathies using random urine specimens

Profile Information

Test ID Reporting Name Available Separately Always Performed
MPTRU M-protein Mass-Fix, Random, U No Yes
RPEU Protein Electrophoresis, Random, U No Yes
RPTU2 Protein/Creatinine Ratio, Random, U Yes, (RPTU1) Yes

Testing Algorithm

The following algorithms are available:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

Method Name

MPTRU: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)

RPEU: Agarose Gel Electrophoresis

RPTU2: Turbidimetry/Enzymatic Colorimetric Assay

Reporting Name

M-protein Studies, Random, U

Specimen Type

Urine

Specimen Minimum Volume

30 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  5 days
  Ambient  24 hours

Reference Values

CREATININE:

≥18 years old: 16-326 mg/dL

Reference values have not been established for patients younger than 18 years of age.

 

PROTEIN/CREATINE RATIO:

≥18 years: <0.18 mg/mg creatinine

Reference values have not been established for patients younger than 18 years of age.

 

ELECTROPHORESIS, PROTEIN:

The following fractions, if present, will be reported as mg/dL:

Albumin

Alpha-1 globulin

Alpha-2 globulin

Beta globulin

Gamma globulin

No reference values apply to random urines.

 

MASS-FIX M-PROTEIN ISOTYPE:

M-protein Isotype MS:

No monoclonal protein detected

 

Flag M-protein Isotype MS:

Negative

Day(s) Performed

Monday through Friday

Report Available

4 to 6 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84156

82570

84166

0077U

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RMPU M-protein Studies, Random, U 101909-0

 

Result ID Test Result Name Result LOINC Value
607975 Albumin 6942-7
617119 M-protein Isotype MS, Random, U In Process
PTCN1 Protein, Total, Random, U 2888-6
617120 Flag M-protein Isotype MS, Random, U No LOINC Needed
CRTR1 Creatinine, Random, U 2161-8
607976 Alpha-1 globulin 9734-5
607977 Alpha-2 globulin 38190-5
PCRT1 Protein/Creatinine Ratio 2890-2
607978 Beta globulin 9744-4
607979 Gamma globulin 9745-1
33044 A/G Ratio 44293-9
33045 M spike 40661-1
33046 M spike 40661-1
33047 Impression 49299-1